Interleukin-4 inhibits cyclo-oxygenase-2 expression and prostaglandin E2production by human mature dendritic cells
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چکیده
منابع مشابه
Interleukin-4 inhibits prostaglandin E2 production by freshly prepared adherent rheumatoid synovial cells via inhibition of biosynthesis and gene expression of cyclo-oxygenase II but not of cyclo-oxygenase I.
OBJECTIVE To characterise the effect of interleukin-4 (IL-4) on the biosynthesis of cyclo-oxygenases I (COX I) and II (COX II), the rate limiting enzymes of the synthesis of prostaglandin E2 (PGE2), in freshly prepared rheumatoid synovial cells. METHODS Adherent synovial cells were obtained from rheumatoid synovium by collagenase digestion. The concentrations of PGE2 in culture supernatants w...
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The results indicate that haptoglobin may account for at least part of the inhibitor activity of plasma or serum. This seems to be consistent with the finding that administration of glucocorticoids in rats induced parallel changes in plasma inhibitor activity and haptoglobin concentration. However, no clear relationship between the haptoglobin concentration and the inhibitory actions of several...
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ژورنال
عنوان ژورنال: Immunology
سال: 2007
ISSN: 0019-2805,1365-2567
DOI: 10.1111/j.1365-2567.2006.02482.x